EXPERIMENTAL STUDY OF THE POSSIBILITY OF DETERMINING THE OPTICAL DENSITY OF PLASMA OF VENOUS BLOOD TO MONITOR THE COURSE OF THE INTRA -ABDOMINAL INFLAMMATORY PROCESS

Early diagnosis of postoperative inflammatory intra-abdominal complications is an urgent issue due to the lack sufficiently informative methods. Our previous studies revealed that measurement venous blood plasma optical density parameters (ODVBP) at a wavelength l = 310 nm criterion for presence and destructive pathology abdominal organs. Therefore, it would be logical assume such indicator can used assess activity process after surgery.
 The purpose study: possibility determining ODVBP surgery in experiment.
 Materials 50 white non-linear rats with models acute peritonitis, which was modeled by puncture injection 20% autofecal mixture dose 1 ml per 100 g weight. 12 hours initiation laparotomy performed, peritoneal cavity washed decamethoxin solution. After 6, 12, 24 48 hours, relaparotomy parietal peritoneum taken histological examination from jugular vein. study carried out on Agilent Cary 100/300 Series UV-Vis spectrophotometer. Animals were removed experiment decapitation. Inhalational sevoflurane anesthesia anesthetize animals. Statistical calculation research results using Microsoft® Office Excel spreadsheets (build 11.5612.5703). Testing law distribution samples normality Shapiro-Wilk test. Wilcoxon test hypothesis equality means.
 Results. days laparotomy, animals showed signs purulent peritonitis. 6 washing, edema, desquamation mesothelium, small number polymorphonuclear leukocytes (PLL) lymphocytes. growth edema observed, mesothelium maintained, infiltration increased. In future, subsidence observed.
 Against background regression inflammation washing cavity, decreased statistically significantly. against some increase inflammation, indicators increased slightly. moderate decrease significant appearance regeneration processes, significantly decreased, almost limits normal values.
 obtained data indicate determination promising use under clinical conditions control period. A will absence complications, while their possible development. However, this requires research.
 Conclusions:
 
 According experimental data, peritoneum, significantly.
 case activation process, increase.
 prospects application evaluating relevant studies.